Oral sustained release formulations design and evaluation edited by avraham yacobi and eva halperin walega a wheaton co exeter uk 1988 263 pp isbn 0 08 036075 0 3950. Oral sustained release formulations design and evaluation 1st edition by avraham yacobi author eva halperin walega editor isbn 13 978 0080360751 isbn 10 0080360750 why is isbn important isbn this bar code number lets you verify that youre getting exactly the right version or edition of a book the 13 digit and 10 digit formats both work scan an isbn with your phone use the amazon . An oral sustained release floating tablet formulation of metformin hcl was designed and developed effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc peo polymer combination respectively tablet composition was optimized by response surface methodology rsm. The main objective of the present work was to develop sustained release matrix tablets of water soluble tramadol hydrochloride using different polymers viz hydroxy propyl methyl cellulose hpmc and natural gums like karaya gum kg and carrageenan cg varying ratios of drug and polymer like 11 and 12 were selected for the study after fixing the ratio of drug and polymer for control the . This book differs from most in its focus on oral controlled release formulation design and process development it also covers the related areas like preformulation biopharmaceutics in vitro in vivo correlations ivivc quality by design qbd and regulatory issues